L’équipe de neurochirurgie de la Clinique de l’Union participe à la publication d’une étude sur les biomarqueurs en IRM de la distribution des cellules souches tumorales au sein des glioblastomes (tumeurs cérébrales primitives les plus fréquentes, et les plus agressives).
https://www.mdpi.com/2072-6694/14/11/2803
Simple Summary
Glioblastoma stem-like cells (GSCs) are known to be aggressive and radio-resistant and proliferate heterogeneously in preferred environments. Additionally, quantitative diffusion and perfusion MRI biomarkers provide insight into the tissue micro-environment. This study assessed the sensitivity of these imaging biomarkers to GSCs in the hyperintensities-FLAIR region, where relapses may occur. A total of 16 patients underwent an MRI session and biopsies were extracted to study the GSCs. In vivo and in vitro biomarkers were compared and both Apparent Diffusion Coefficient (ADC) and relative Cerebral Blood Volume (rCBV) MRI metrics were found to be good predictors of GSCs presence and aggressiveness.